Non-invasive Monitoring of Drugs Bioavailability by Tissue Impedance Measurement

Abstract

Abstract

Topical administration and transdermal delivery are advantageous in comparison with systemic administration routes because complications as first-pass metabolism, toxicity, and side effects are attenuated for the patient. Their effectiveness is evaluated by numerous studies in laboratory. However, performance outside of a laboratory, in the context of daily clinical application, is less investigated. 

After an introduction on EIS for prosthesis osseointegration diagnostics in audiology and Artificial Intelligence for model definition in EIS, this tutorial presents a measurement methods (in aesthetic medicine) to evaluate the amount of a substance delivered into a tissue . A second measurement method for indirectly assessing the insulin bioavailability is discussed. The leakage of a given amount of insulin produces a corresponding variation in the measured equivalent impedance in the administration volume.

Keywords

Electrochemical Impedance Spectroscopy, drug bioavailability assessment,  transdermal delivery, personalized medicine, 

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